顾春艳
顾春艳（邮箱：guchunyan@njucm.edu.cn），博士，教授，博士生导师，澳门新莆京5088app官网病理学与病理生理学系主任。2009.12-2015.10，美国犹他大学学院、爱荷华大学学院博士后；江苏省“六大人才高峰”创新团队带头人；江苏省优秀青年科学基金获得者；江苏省“333高层次人才培养工程”第三层次培养对象；江苏省“双创计划”团队项目核心成员；中华医学会病理学分会病理学教学工作委员会委员、中国抗癌协会抗癌药物专委会青年委员、中华中医药学会中药毒理与安全性研究分会委员、中国老年学和老年医学学会老年病学会血液学专家委员会常务委员、江苏省病理生理学会常务理事、民盟江苏省委青委会副主任委员；Signal transduction and targeted therapy、Molecular Cancer、British Journal of Pharmacology、Journal of Ethnopharmacology等学术杂志审稿人。
主要从事恶性肿瘤的发病机制、病理研究与药物靶点发现研究，主持国家自然科学基金项目5项、江苏省“六大人才高峰”创新团队项目1项、江苏省自然科学基金项目2项、江苏省方剂高技术研究重点实验室重点项目1项，参与江苏省“双创计划”团队项目1项；发表SCI论文逾50篇，累计影响因子逾400；获得国家发明专利授权6项；获得江苏省研究生教育改革成果优秀奖；负责国家研究生教育智慧教育平台首批上线的研究生课程《高等病理学》；主持江苏省研究生教育教学改革课题1项，澳门新莆京5088app官网中西医临床医学品牌专业教学改革研究开放课题重点课题1项，澳门新莆京5088app官网本科课程思政精品课程1门。指导本科生获得3项国家级大学生创新创业训练计划立项、2022年江苏省“挑战杯”大学生创业计划竞赛银奖、“互联网+”江苏省选拔赛暨江苏省大学生创新创业大赛二等奖、三等奖各1项。
近三年代表性研究论文：
(1)Chunyan Gu; Wang Wang; Xiaozhu Tang; Tingting Xu; Yanxin Zhang; Mengjie Guo; Rongfang Wei; Yajun Wang; Artur Jurczyszyn; Siegfried Janz; Meral Beksac; Fenghuang Zhan; Anja Seckinger; Dirk Hose; Jingxuan Pan#; Ye Yang#. CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma, Molecular Cancer, 2021, 20:84. （医学一区，IF：41.444）
(2)Xiaozhu Tang; Mengjie Guo; Pinggang Ding; Zhendong Deng; Mengying Ke; Yuxia Yuan; Yanyan Zhou; Zigen Lin; Muxi Li; Chunyan Gu#; Xiaosong Gu#; Ye Yang#. BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability, Signal Transduction and Targeted Therapy, 2021, 6:361. （医学一区，IF：38.104）
(3)Yuanjiao Zhang; Jinjun Qian; Chunyan Gu#; Ye Yang#. Alternative splicing and cancer: a systematic review, Signal Transduction and Targeted Therapy, 2021, 6:78. （医学一区，IF：38.104）
(4)Mengying Ke; Liqing Kang; Ling Wang; Shu Yang; Yajun Wang; Haiyan Liu; Chunyan Gu#; Hongming Huang#; Ye Yang#. CAR-T therapy alters synthesis of platelet‑activating factor in multiple myeloma patients, Journal of Hematology & Oncology, 2021, 14:90. （医学一区，IF：23.168）
(5)Fengjie Jiang; Xiaozhu Tang; Chao Tang; Zhen Hua; Mengying Ke; Chen Wang; Jiamin Zhao; Shengyao Gao; Artur Jurczyszyn; Siegfried Janz; Meral Beksac; Fenghuang Zhan; Chunyan Gu#; Ye Yang#. HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A‑dependent stabilization of ILF3 mRNA, Journal of Hematology & Oncology, 2021, 14:54. （医学一区，IF：23.168）
(6)Rongfang Wei; Yan Zhu; Yuanjiao Zhang; Wene Zhao; Xichao Yu; Ling Wang; Chunyan Gu#; Xiaosong Gu#; Ye Yang#.AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation, Cancer communications, 2022.8.30.（医学一区，IF：15.283）
(7)Chao Tang; Mengying Ke; Xichao Yu; Shanliang Sun; Xian Luo; Xin Liu; Yanyan Zhou; Ze Wang; Xing Cui#; Chunyan Gu#; Ye Yang#. GART Functions as a Novel Methyltransferase in the RUVBL1/β-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer. Advanced Science, 2023, 10(25): e2301264. （生物化学一区，IF：15.1）
(8)Rongfang Wei; Xing Cui; Jie Min; Zigen Lin; Yanyan Zhou; Mengjie Guo; Xiaojuan An; Hao Liu; Siegfried Janz; Chunyan Gu#; Hongbo Wang#; Ye Yang#. NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma, Acta Pharmaceutica Sinica B, 2022;12(8):3313-3325. （医学一区，IF：14.903）
(9)Hongbo Wang#; Qinghai Meng; Jinjun Qian; Muxi Li; Chunyan Gu#; Ye Yang#. Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer, Pharmacology & therapeutics, 2022, 234:108123. （医学一区，IF：13.4）
(10)Chunyan Gu; Ting Lu; Wang Wang; Miaomiao Shao; Rongfang Wei; Mengjie Guo; Rui Li; Li Qiao; Ye Hu; Fenghuang Zhan; Anja Seckinger; Dirk Hose; Ye Yang#. RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma, Leukemia, 2021, 35(6):1803-1807. （医学一区，IF：12.883）
(11)Chunyan Gu; Xichao Yu; Xiaozhu Tang; Leilei Gong; Jingquan Tan; Yuanjiao Zhang;
Huili Zheng; Ze Wang; Chenqian Zhang; Yejin Zhu; Zuojian Zhou; Heming Yu; Kai Xu; Jinao Duan#; Xiaosong Gu#; Ye Yang#. Lycium barbarum L.-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation, Engineering, 2023. （工程技术一区，IF: 12.8）
(12)Xiaozhu Tang; Zhendong Deng; Pinggang Ding; Wanting Qiang; Yue Lu; Shengyao Gao; Ye Hu; Ye Yang#; Juan Du#; Chunyan Gu#. A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing, Journal of Experimental & Clinical Cancer Research, 2022, 41(1):85.（医学一区，IF：12.658）
(13)Chunyan Gu; Yajun Wang; Lulin Zhang; Li Qiao; Shanliang Sun; Miaomiao Shao; Xiaozhu Tang; Pinggang Ding; Chao Tang; Yuhao Cao; Yanyan Zhou; Mengjie Guo; Rongfang Wei; Nianguang Li#; Yibei Xiao#; Jinao Duan#; Ye Yang#. AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma, Journal of experimental & clinical cancer research, 2022, 41(1):11. （医学一区，IF：12.658）
(14)Renjie Dou; Jinjun Qian; Wei Wu; Yanxin Zhang; Yuxia Yuan; Mengjie Guo; Rongfang Wei; Shu Yang; Artur Jurczyszyn; Siegfried Janz; Meral Beksac; Chunyan Gu#; Ye Yang#. Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma, Cell Death & Disease, 2021, 12:206. （医学二区，IF：9.685）
(15)Ying Chen; Jinjun Qian; Pinggang Ding; Wang Wang; Xinying Li; Xiaozhu Tang; Chao Tang; Ye Yang#; Chunyan Gu#. Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation. Cell Death & Disease, 2022;13(9):822. （医学二区，IF：9.685）
(16)Zhen Hua; Rongfang Wei; Mengjie Guo; Zigen Lin; Xichao Yu; Xinying Li; Chunyan Gu#; Ye Yang#. YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis, Oncogene, 2022, 41(10):1482-1491. （医学一区，IF：8.756）
(17)Rui Li; Mengying Ke; Mingming Qi; Zhenru Han; Yuhao Cao; Zhendong Deng; Jinjun Qian#;Ye Yang#; Chunyan Gu#. G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti‑oxidant production and activating Wnt/β‑catenin pathway, Experimental Hematology & Oncology, 2022, 11(1):77. (医学一区，IF：8.593)
(18)Yuanjiao Zhang; Xichao Yu; Rongze Sun; Jie Min; Xiaozhu Tang; Zigen Lin; Siyuan Xie; Xinying Li; Shengfeng Lu; Zhidan Tian; Chunyan Gu#; Lesheng Teng#; Ye Yang#. Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication, Clinical and Translational Medicine, 2022;12(2):e684.（医学一区，IF：8.554）
