杨 烨
杨烨（邮箱：yangye876@sina.com），博士，教授，博士生导师，现任澳门新莆京5088app官网科技处处长，兼任中国药理学会生化与分子药理学专委员会副秘书长、中国药理学会生化与分子药理学专委员会青年副主任委员、中国抗癌协会中西医整合肿瘤专业委员会常务理事、中国老年学和老年医学学会老年病学分会血液学专家委员副主任委员、中国民族医药学会药理与毒理学分会常务理事、中国医药教育协会整合医学教育分会理事、江苏省药理学会理事、江苏省中医药学会理事等。
先后入选江苏省特聘教授、国家级青年人才项目、江苏省“双创团队”领军人才、江苏省“333工程”第二层次培养对象、江苏省“双创人才”、江苏省“六大人才高峰”A类高层次人才培养对象、澳门新莆京5088app官网A类特聘教授。荣获江苏省杰出青年基金和第十五届江苏省青年科技奖暨“十大青年科技之星等人才类项目称号。
从事多发性骨髓瘤靶标发现与干预研究，研究成果发表在Cancer Cell、Molecular Cancer、Blood、Signal Transduction and Targeted Therapy、Leukemia、Cancer Research等国际知名期刊上。迄今，共发表SCI科研论文100余篇，总影响因子近600分；申请专利6项，获授权2项。获得江苏省研究生教育改革成果优秀奖。获国家重点研发计划子课题项目、国家自然科学基金、江苏省杰出青年科学基金等近20项国家级、省部级项目资助。发表美国血液病年会会议摘要18篇。
近五年代表性研究论文：
(1)Chunyan Gu; Wang Wang; Xiaozhu Tang; Tingting Xu; Yanxin Zhang; Mengjie Guo; Rongfang Wei; Yajun Wang; Artur Jurczyszyn; Siegfried Janz; Meral Beksac; Fenghuang Zhan; Anja Seckinger; Dirk Hose; Jingxuan Pan#; Ye Yang#. CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma, Molecular Cancer, 2021, 20:84. （医学一区，IF：41.444）
(2)Xiaozhu Tang; Mengjie Guo; Pinggang Ding; Zhendong Deng; Mengying Ke; Yuxia Yuan; Yanyan Zhou; Zigen Lin; Muxi Li; Chunyan Gu#; Xiaosong Gu#; Ye Yang#. BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability, Signal Transduction and Targeted Therapy, 2021, 6:361. （医学一区，IF：38.104）
(3)Yuanjiao Zhang; Jinjun Qian; Chunyan Gu#; Ye Yang#. Alternative splicing and cancer: a systematic review, Signal Transduction and Targeted Therapy, 2021, 6:78. （医学一区，IF：38.104）
(4)Dongdong Sun; Weiwei Tao; Feng Zhang; Weixing Shen; Jiani Tan; Liu Li; Qinghai Meng; Yugen Chen; Ye Yang#; Haibo Cheng#. Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling, Signal Transduction and Targeted Therapy, 2020, 5:174. （医学一区，IF：38.104）
(5)Mengying Ke; Liqing Kang; Ling Wang; Shu Yang; Yajun Wang; Haiyan Liu; Chunyan Gu#; Hongming Huang#; Ye Yang#. CAR-T therapy alters synthesis of platelet‑activating factor in multiple myeloma patients, Journal of Hematology & Oncology, 2021, 14:90. （医学一区，IF：23.168）
(6)Fengjie Jiang; Xiaozhu Tang; Chao Tang; Zhen Hua; Mengying Ke; Chen Wang; Jiamin Zhao; Shengyao Gao; Artur Jurczyszyn; Siegfried Janz; Meral Beksac; Fenghuang Zhan; Chunyan Gu#; Ye Yang#. HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A‑dependent stabilization of ILF3 mRNA, Journal of Hematology & Oncology, 2021, 14:54. （医学一区，IF：23.168）
(7)Rongfang Wei; Yan Zhu; Yuanjiao Zhang; Wene Zhao; Xichao Yu; Ling Wang; Chunyan Gu#; Xiaosong Gu#; Ye Yang#.AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation, Cancer communications,2022.8.30. （医学一区，IF：15.283）
(8)Rongfang Wei; Xing Cui; Jie Min; Zigen Lin; Yanyan Zhou; Mengjie Guo; Xiaojuan An; Hao Liu; Siegfried Janz; Chunyan Gu#; Hongbo Wang#; Ye Yang#. NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma, Acta Pharmaceutica Sinica B, 2022;12(8):3313-3325. （医学一区，IF：14.903）
(9)Hongbo Wang#; Qinghai Meng; Jinjun Qian; Muxi Li; Chunyan Gu#; Ye Yang#. Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer, Pharmacology & therapeutics, 2022, 234:108123. （医学一区，IF：13.4）
(10)Chunyan Gu; Ting Lu; Wang Wang; Miaomiao Shao; Rongfang Wei; Mengjie Guo; Rui Li; Li Qiao; Ye Hu; Fenghuang Zhan; Anja Seckinger; Dirk Hose; Ye Yang#. RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma, Leukemia, 2020.09.08. （医学一区，IF：12.883）
(11)Xiaozhu Tang; Zhendong Deng; Pinggang Ding; Wanting Qiang; Yue Lu; Shengyao Gao; Ye Hu; Ye Yang#; Juan Du#; Chunyan Gu#. A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing, Journal of Experimental & Clinical Cancer Research, 2022, 41(1):85.（医学一区，IF：12.658）
(12)Chunyan Gu; Yajun Wang; Lulin Zhang; Li Qiao; Shanliang Sun; Miaomiao Shao; Xiaozhu Tang; Pinggang Ding; Chao Tang; Yuhao Cao; Yanyan Zhou; Mengjie Guo; Rongfang Wei; Nianguang Li#; Yibei Xiao#; Jinao Duan#; Ye Yang#. AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma, Journal of experimental & clinical cancer research, 2022, 41(1):11. （医学一区，IF：12.658）
(13)Chunyan Gu; Haibo Cheng; Hongbao Yang; Yong Bian; Yaohui Wang; Yifen Zhang; Michael Pisano; Gang Hu#; Ye Yang#. MK2 is a therapeutic target for high-risk multiple myeloma, Haematologica, 2018.3.22. （医学一区，IF：11.047）
(14)Chunyan Gu; Carol Holman; Xuefang Jing; Ramakrishna Sompallae; Michael Tomasson; Dirk Hose; Anja Seckinger; Fenghuang Zhan; Guido Tricot; Hartmut Goldschmidt; Ye Yang#; Siegfried Janz#. Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome, Blood Cancer Journal, 2018, 8(2): 0-22. （医学一区，IF：9.812）
(15)Renjie Dou; Jinjun Qian; Wei Wu; Yanxin Zhang; Yuxia Yuan; Mengjie Guo; Rongfang Wei; Shu Yang; Artur Jurczyszyn; Siegfried Janz; Meral Beksac; Chunyan Gu#; Ye Yang#. Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma, Cell Death & Disease, 2021, 12:206. （医学二区，IF：9.685）
(16)Ying Chen; Jinjun Qian; Pinggang Ding; Wang Wang; Xinying Li; Xiaozhu Tang; Chao Tang; Ye Yang#; Chunyan Gu#. Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation. Cell Death & Disease, 2022;13(9):822. （医学二区，IF：9.685）
(17)Zhen Hua; Rongfang Wei; Mengjie Guo; Zigen Lin; Xichao Yu; Xinying Li; Chunyan Gu#; Ye Yang#. YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis, Oncogene, 2022, 41(10):1482-1491.（医学一区，IF：8.756）
(18)Yuanjiao Zhang; Xichao Yu; Rongze Sun; Jie Min; Xiaozhu Tang; Zigen Lin; Siyuan Xie; Xinying Li; Shengfeng Lu; Zhidan Tian; Chunyan Gu#; Lesheng Teng#; Ye Yang#. Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication, Clinical and Translational Medicine, 2022;12(2):e684.（医学一区，IF：8.554）
(19)Ting Lu; Wen-e Zhao; Fang Zhang; Xiaohong Qi; Ye Yang#; Chunyan Gu#. Lycium barbarum polysaccharides attenuate rat anti-Thy-1 glomerulonephritis through mediating pyruvate dehydrogenase, Biomedicine & Pharmacotherapy, 2019, 116 (2019): 109020. （医学二区，IF：7.419）
(20)Dongdong Sun; Weixing Shen; Feng Zhang; Huisen Fan; Changliang Xu; Liu Li; Jiani Tan; Yunjie Miao; Haibin Zhang; Ye Yang#; Haibo Cheng#. α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells, Biomedicine & Pharmacotherapy, 2018, 101 (2018):107–114. （医学二区，IF：7.419）
(21)Xiaozhu Tang; Hongyan Ren; Mengjie Guo; Jinjun Qian; Ye Yang#; Chunyan Gu#. Review on circular RNAs and new insights into their roles in cancer, Computational and Structural Biotechnology Journal, 2021, 19 (2021): 910-928.（医学二区，IF：6.155）
