李永明

李永明（邮箱：liyongming1979@sina.com），理学博士，教授，硕士生导师，中国细胞生物学学会会员。先后在美国北达科他州立大学、密歇根大学和乔治华盛顿大学担任博士后和研究助理教授，2015年通过“其震工程”人才引进计划到大连医科大学工作，2018年4月到澳门新莆京5088app官网工作，入选江苏省“六大人才高峰”高层次人才培养对象。

主要从事基因组不稳定性与肿瘤发生发展、DNA损伤修复机制以及肿瘤化疗耐药机制的课题研究，主持国家自然学科基金项目2项以及江苏省六大人才高峰资助项目1项。迄今为止，在Nucleic Acids Research、Oncogene、Cancer Research、J Biol Chem等国际医学生物学期刊上发表SCI论文20余篇。担任Cancer Medicine、International Journal of Oncology 、 J Biol Chem等学术杂志审稿人。

近年五篇代表性研究论文

[1]Muhammad Khan, Amara Maryam, Muhammad Zubair Saleem, Hafiz Abdullah Shakir, Javed Iqbal Qazi, Yongming Li*, Tonghui Ma*. “Brevilin A induces ROS-dependent apoptosis and suppresses STAT3 activation by direct binding in human lung cancer cells”. Journal of Cancer, 2020; 11(13): 3725-3735. 

[2]Chi-Wei Chen＃, Yongming Li＃, Shuya Hu, Wei Zhou1, Yunxiao Meng1, Zongzhu Li1, Yi Zhang, Jing Sun, Zhou Bo, Melvin L. DePamphilis, Yun Yen, Zhiyong Han, Wenge Zhu. “ DHS (trans−4,4′-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2) ”. Oncogene,2019, 38(13):2364-2379 . 

[3]Yongming Li＃, Zongzhu Li＃, Ruiqin Wu, Zhiyong Han and Wenge Zhu. “And-1 is required for homologous recombination repair by regulating DNA end resection”. Nucleic Acids Research, 2017, 45(5): 2531–2545.

[4]He Liu, Bin Wu, Yang Ge, Jiaxin Xu, Shijie Song, Changyuan Wang, Jihong Yao, Kexin Liu, Yanxia Li, Yongming Li*, Xiaodong Ma*. “Phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with enhanced activity against pancreatic cancer cell lines”. Bioorganic & Medicinal Chemistry, 2017, 25:6313-6321.

[5]Yongming Li＃, Haijie Xiao＃, Christelle de Renty, AN Jaramillo-Lambert,  et,al. “The Involvement of Acidic Nucleoplasmic DNA-binding Protein (And-1)  in the Regulation of Prereplicative Complex (pre-RC) Assembly in Human Cells”. JBC, 2012, 287(51): 42469-42479.