刘武昆
刘武昆,药物化学博士,教授,博士生导师。2008年赴德国柏林自由大学药学院Ronald Gust教授课题组攻读药物化学专业博士学位,2012年博士毕业后进入美国约翰霍普金斯大学学院刘钧教授(Prof. Jun O. Liu)课题组从事博士后研究工作。2017年于澳门新莆京5088app官网工作。先后入选江苏特聘教授、江苏省“双创团队”核心成员、江苏省“333人才工程”培养对象(第三层次)、江苏省“六大人才高峰”高层次人才培养对象、中国化学会“中国青年化学家元素周期表”铑元素代言人。
主要从事新型硫氧还蛋白还原酶 (thioredoxin reductase, TrxR) 抑制剂的设计、合成与抗肿瘤活性研究。主持国家自然科学基金等多项课题。以第一或通讯作者在药物化学及相关领域杂志Chem. Soc. Rev.(2篇)、Coord. Chem. Rev.(3篇)、Redox Biol.(1篇)、J. Med. Chem.(7篇)、Eur. J. Med. Chem.(7篇)、Chem. Eur. J.等上发表论文30余篇。目前是Med. Res. Rev.、J. Med. Chem.等学术杂志审稿人。
近年五篇代表性通讯作者论文
[1] Yunlong Lu, Xiaoyan Ma, Xingyu Chang, Zhenlin Liang, Lin Lv, Min Shan, Qiuyue Lu, Zhenfan Wen, Ronald Gust*, Wukun Liu*. Recent development of gold(I) and gold(III) complexes as therapeutic agents for cancer diseases. Chemical Society Reviews 2022, 51, 5518-5556.
[2] Zhongren Xu, Jianqiang Xu, Shibo Sun, Wei Lin, Yongming Li, Qiuyue Lu, Fuwei Li, Zhibin Yang, Yunlong Lu, Wukun Liu*. Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma. Redox Biology 2022, 54, 102351.
[3] Zhibin Yang#, Sheng Huang#, Yu Liu, Xingyu Chang, Xi Li, Zhongren Xu, Shiyu Wang, Yuan Liu*, Wukun Liu*. Biotin-targeted Au(I) radiosensitizer for cancer synergistic therapy by intervening redox homeostasis and inducing ferroptosis. Journal of Medicinal Chemistry 2022, 65(12), 8401-8415.
[4] Mianli Bian, Rong Fan, Zhibin Yang, Yanan Chen, Zhongren Xu, Yunlong Lu, Wukun Liu*. Pt(II)-NHC complex induces ROS-ERS related DAMPs balance to harness immunogenic cell death in hepatocellular carcinoma. Journal of Medicinal Chemistry 2022, 65(3), 1848-1866.
[5] Mianli Bian#, Rong Fan#, Guizhi Jiang, Yingxiang Wang, Yunlong Lu, Wukun Liu*. Halo and pseudohalo gold(I)-NHC complexes derived from 4,5-diarylimidazoles with excellent in vitro and in vivo anticancer activity against HCC. Journal of Medicinal Chemistry 2020, 63(17), 9197-9211.