孙中楼(邮箱:Zhonglou.Sun@njucm.edu.cn),博士,教授,博士研究生导师,江苏省特聘教授,现任职澳门新莆京5088app官网学院。
近年来主要从事血管稳定性与疾病关系的研究,主要围绕小GTP酶活化蛋白(GTPase)ARF6 (Small GTPase ADP ribosylation factor 6)在血管中的细胞生物学功能展开研究,探索ARF6的靶向抑制剂(NAV-2729)是否可以作为治疗神经退行性疾病(如多发性硬化症、阿尔茨海默症、亨廷顿病、帕金森氏症等)、炎性疾病(关节炎、败血症)等疾病的潜在的临床药物。主持的科研项目包括江苏省特聘教授自然科学类资助项目、澳门新莆京5088app官网高层次人才引进科研启动项目,相关研究成果发表SCI学术论文10余篇。
代表性研究论文
1. Richards, J. R., Shin, D., Pryor, R., Sorensen, L. K., Sun, Z., So, W. M., ... & Yoo, J. H. Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis. Oncogene, 2023, 42(35), 2629-2640.
2. Sun, Z., Zhao, H., Fang, D., Davis, C. T., Shi, D. S., Lei, K., ... & Zhu, W. (2022). Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling. Neuron, 110(19), 3106-3120.
3. Sun, Z.#, Orozco-terWengel, P.#, Chen, G., Sun, R., Sun, L., Wang, H., ... & Zhang, B. (2021). Spatial dynamics of Chinese Muntjac related to past and future climate fluctuations. Current Zoology, 67(4), 361-370.
4. Sun, Z., Wang, H., Zhou, W., Shi, W., Zhu, W., & Zhang, B. (2019). How rivers and historical climate oscillations impact on genetic structure in Chinese Muntjac (Muntiacus reevesi)? Diversity and Distributions, 25(1), 116-128.
5. Sun, Z., Pan, T., Hu, C., Sun, L., Ding, H., Wang, H., ... & Zhang, B. (2017). Rapid and recent diversification patterns in Anseriformes birds: Inferred from molecular phylogeny and diversification analyses. PLoS One, 12(9), e0184529.